When Oliver Cromwell, Lord Protector of England was being painted by the noted artist, Sir Peter Leley, he asked that any imperfections he had not be painted out, but rather he be portrayed "warts and all." While he coined the phrase, many people began to use this phrase worldwide. The phrase has come to mean bearing everything and not hiding things from the world.
This phrase "warts and all," was most likely inspired by a normal, common wart that Oliver Cromwell might have had. Warts are fairly common and can come in many forms and appear on various parts of the body. Plantar warts appear on the feet, genital warts appear on the genitals and other types of warts may appear on other areas of the body. While it is the job of the body's immune system to regulate the spread of these warts, there are times that the body can not handle the situation and a doctor should be seen to take care of the situation.
In treating warts and to prevent them from spreading it is recommended that the patient does not brush, comb, clip or shave the area where warts are located, and a nail clipper or nail […]
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One of the most embarrassing diseases that an individual can get is genital warts. Genital warts are a particular type of sexually transmitted diseases, usually caused by HPV (human pappllomavirus). It can be transmitted from one partner to another by direct skin contact during sexual intercourse. Any kind of sexual activity, such as oral, anal or vaginal sex can lead to transmission of genital warts from a healthy partner to another.Genital warts can be easily identified as a genital HPV infection. Severe case of genital warts can also lead to cervical cancer in women. Many people may tend to confuse genital warts with other benign anal warts but genital warts are entirely different. They can be identified as fleshy, raised growths on the genital areas of an individual. They generally occur in clusters. Genital warts can be extremely small or can even grow eventually to transform into large masses of clusters in the penis area.Genital warts are most commonly seen in men. Men are affected by genital warts on specific areas, such as the tip of penis. Some other genital areas may also include shaft of the penis, the area around the penis and on the scrotum. On the other […]
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Toll-like receptor 7 (TLR7), is an immune gene possessed by humans, other mammals and additionally in avian species playing a significant role in initiating antiviral immune responses. It belongs to the evolutionarily conserved Toll-like receptor family. The TLR7 sequence encodes a 1049 amino acid protein with a calculated molecular weight of 121 kDa. Like all other members of the TLR family, TLR7 contain an ectodomain with multiple leucine-rich repeats (LRRs) and a cytoplasmic domain homologous to that of the human interleukin-1 (IL-1) receptor. TLR7 is most closely related to TLR8 and TLR9 with 43% and 36% overall amino acid sequence identity, respectively and thus along with TLR8 and TLR9 constitutes a new sub-family of the TLRs.
In vivo, TLR7 mRNA is expressed in lung, placenta, spleen, lymph node, and tonsil. TLR7 mRNA expression is highest in monocytes, B cells, and DC. In vitro, TLR7 mRNA expression is upregulated in THP-1 cells upon PMA-induced differentiation. TLR7 is highly upregulated by exposure to IL-6 and to a slightly lesser extent by autocrine IFN-γ, IL-1β. TLR7 mRNA expression in THP-1 cells is elevated after exposure to both Gram-positive and Gram-negative bacteria. Ex vivo, expression of TLR7 is elevated after exposure to both Gram-positive […]
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