How Do Experts Treat Gout? Part 2

In an earlier article I discussed the aims of treatment and some of the pitfalls in treating gout. In this article I will discuss types of treatment.
Before jumping into the exact drugs used to treat gout, let0s look at the metabolic pathway that explains why gout develops.
Foods that are high in purines (shell fish, red meat, beer, wine, etc.) are converted to hypoxanthine and then to xanthine. Xanthine is then transformed into uric acid. Patients who have a metabolic abnormality that causes them to produce an excessive amount of uric acid will have a big problem if the ingest a diet high in purines.
There are three major drug treatment strategies for gout:
0 Uricosurics (these are drugs that cause patients to eliminate uric acid in the urine). Examples include probenecid, losartan, and fenofibrate). These drugs should be used in people who are under the age of 80 with normal kidney function, who are not already putting out more than 800 mgs of uric acid per day in their urine, and who are not kidney stone formers. Patients should be adequately hydrated and avoid aspirin doses higher than a baby aspirin per day because of potential drug interaction.
0 Drugs that reduce urate […]

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